The most common symptoms of TBI in milder cases are disturbances of consciousness, headaches, dizziness, disturbances in balance, nausea and vomiting.
However, more serious injuries lead to extensive brain damage due to disruption of vessels and an increase in intracranial pressure. In this case, severe symptoms appear in the form of paralysis or limb paralysis, speech disorders or dementia.
Rehabilitation for trauma patients is typically longer. The administration of CBD oil can assist patients in the recovery process. The benefits of using cannabidiol to protect the condition of the brain after injury is due to the fact that CBD has shown therapeutic potentials in my cases.
According to neurologist Mayo, Eugene L. Scharf’s scientific articles published 2017. The CBD oil affects more than 65 molecular targets (mainly receptors) located in various parts of the human body. This cannabinoid has very high activity against the molecular effects of cerebral ischemia. CBD has shown to reduce the damage of this organ and improve the ability to recover (motor, cognitive) functions in animal models of stroke and traumatic brain injury.
2010 Report British Journal
According to a 2010 report published in the British Journal of Pharmacology, the administration of cannabidiol, directly in the form of injections, around the damaged brain tissue reduces the size of these pathological changes.
A damaged brain can be extremely malleable when it comes to regeneration, but there is some limitation – the time that elapses from the moment of injury to therapeutic intervention. Taking action as quickly as possible prevents degenerating or delaying the degenerative “domino effect” that occurs as a result of brain damage. Researchers have demonstrated that CBD has a strong and long-lasting neuroprotective effect if the compound is given up to twelve hours after the onset of ischemia.
Although cannabidiol itself has a little direct affinity for cannabinoid receptors – (CB1 and CB2), other mechanisms are responsible for the neuroprotective effect.
2016 Research UK
In 2016, researchers from the University of Nottingham (UK) reported that CBD protects the blood-brain barrier against hypoxia caused by oxygen and glucose deficiency by activating the 5-HT1A serotonin receptor and the PPAR-gamma nuclear receptor. Cannabidiol also acts on elements of the endocannabinoid system, and as a result of its interference, the level of neuroprotective endocannabinoids in the brain increases.
2016 Research Conference
At one of the International Society of Research’s conferences in 2016, scientists compared the impact of CBD and local hypothermia (cooling) on brain damage for newborn piglets caused by ischemic injury. It is worth mentioning that local hypothermia is one of the methods of stroke therapy. In an animal model, administration of CBD was more effective than the use of hypothermia in the protection of brain functions of piglets. Preliminary data also suggest that the combination of cannabidiol and local hypothermia may give the best results.
Damage to the brain is caused not only by violent, individual injuries or ischemic strokes but can also be the result of numerous, minor shocks experienced over a longer period of time. Such types of damage often occur in athletes and lead to the occurrence of neurological problems later in life, and could also accelerate the development of dementia.
Perhaps, in this area, CBD oil could render pro-health achievements, especially since the WADA (World Anti-Doping Organization) has deleted cannabidiol from the list of prohibited substances and methods (the list has been in force since 2018) . In other worde, CBD is no longer a prohibited substance during and after the competition.
As WADA explains, “synthetic cannabidiol is not a cannabimimetic; however, extracts extracted from cannabis may contain some amounts of THC – a compound that remains a prohibited substance. In addition to THC, other prohibited substances in Cannabinoid are Spice, JWH-018, JWH-073, HU210.
Cannabidiol has an extremely extensive profile of therapeutic properties, including a distinguishing neuroprotective effect in the case of brain injuries which has been proven in preclinical experiments. However, no clinical trials have yet been conducted to establish the effectiveness of CBD in patients with traumatic brain injury.
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