Present in our bodies is an endocannabinoid system. Meaning, our bodies have receptors for such compounds as THC and CBD. The interaction of both compounds via the endocannabinoid system is responsible for the regulation of many physiological processes such as pain, mood, memory, appetite, sleep and immune response.
The chemical structure of cannabidiol (CBD) is similar to that of the natural endocannabinoids which means they can interact with the cannabinoid receptors in the endocannabinoid system.
THC vs. CBD
For over 6o years, CBD oil has not been given as much attention as THC, even though both serve as primary active ingredients in marijuana. CBD first isolation was in 1940, while THC first isolation was in 1964 by Cannabis scientist Raphael Mechoulam.
THC creates the psychotic effect experienced after taking marijuana. CBD, on the other hand, creates therapeutic effects.
The advantages of CBD oil were studied in the 1970s. It was at this point that researchers observed that both THC and CBD share similar properties. Research showed that CBD did not exert any psychoactivity, which implies that it doesn’t get the user high.
As much as the fact that both compounds are related. It is worth mentioning that, they are unique in their own ways. THC contains properties that give you head or body high (psychotropic). On the other hand, CBD doesn’t, rather it contains therapeutic properties that can cure certain ailments.
The mechanism of action for both compounds is independent. However, they do work synergistically together to provide health and healing to the mind and body.
CBD vs THC interaction
As CBD interacts with the CB1 receptor, It modulates the psychotropic effects of THC by impeding its ability to bind to and stimulate the receptor. This process explains why consumers of CBD rich cannabis don’t get “high” as opposed to when THC is consumed in the same proportion.
All evidence shows that CBD is able to mitigate some negative effects of THC by reducing anxiety, short-term memory impairment and euphoria which is often experienced when cannabis is consumed.
According to a research study, a CBD rich products when combined with little THC can convey therapeutic benefits without causing any psychotropic effects.
What is CBD Oil?
CBD oil is extracted from cannabis or hemp plant. A lot of research has disclosed that CBD oil has a myriad of healing properties. However, there is a need for more research to corroborate this fact.
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What is CBD oil used for?
Health Benefits Of Cbd Oil
Some countries have legalized marijuana cultivation, processing, and usage. The reason for this is not far-fetched. The plant is a major source of food, fiber, fuel, and medicine. The marijuana plant is safe and thrives in all climates. It has a long list of benefits.
Like I mentioned earlier, the endocannabinoid system contains special receptors that can only be triggered by substances present in the marijuana plant. Pre-clinical research has shown that CBD has anti-anxiety, anti-seizure, anti-inflammatory, anti-tumor, analgesic, anti-psychotic, anti-tumor, neuroprotective, antioxidant, and analgesic properties.
Mechanism Of CBD In The Body
CBD impacts the body positively and affects our health in so many different ways.
Vanilloid receptors regulate and manage the pain symptoms we experience.
Adenosine receptors manage the depth and quality of our sleep, and also regulates the action of endocannabinoid receptors, controlling energy levels, memory, stress levels, body temperature, appetite among others.
Research has shown that CBD oil has anti-tumor effects on breast carcinoma and glioma which leads to an increase in the death of cancer cells for certain types of cancer.
Medical Benefits Of Cannabidiol: Evidence-based
Cannabidiol has triggered a lot of research interest recently. Before we get into the health benefits of CBD, it is important to know how CBD impacts the body and mind.
Antioxidant and neuroprotective effects
Of all the verified health benefits of CBD oil, what stands out most is the neuroprotective and antioxidant benefit. As indicated in research studies, neuroprotective property in cannabidiol mitigates, prevents or disrupts certain body functions that may cause degeneration of nerve cells and subsequently neural diseases such as Alzheimer’s, Parkinson’s, Stroke, Multiple Sclerosis, etc. They also reduce cerebral swelling which some authorities believe hinders the optimal functioning of the brain and contributes to brain fog and chronic tiredness.
Mood enhancement and anti-anxiety
Research has shown that a lot of people do experience sensations of stress and anxiety relief after taking CBD oil. The oil plays a vital role in relieving stress. Many have reported having experienced calmness inside and out after taking CBD oil.
CBD oil helps effectively in the management of anxiety. According to research, it alters the ways the brain receptors respond to 5_hydroxytryptamine. 5-HT is essential for excellent mental health. Receptors, as we all know, are small proteins linked to the cells that sense and receive chemical stimuli, assisting the cells to respond to various stimuli. A particular study has found that CBD at a dose of 600 mg assisted people with anxiety to deliver a speech at a school. Other studies performed on animals have shown that CBD helps in:-
- Stress relief
- Minimizing the physiological responses to anxiety such as increased heart rate
- Sleep induction in the case of sleep disorders such as insomnia
- An improvement in Post-Traumatic stress disorder (PTSD).
It is speculated that CBD oil helps in the management of epilepsy. Although, the research is yet to be concluded.
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Researchers are trying to evaluate the quantity of CBD required to minimize the frequency of seizures in epileptic patients, alongside its safety measure. According to the American Epilepsy Society, studies on cannabidiol offers much hope for seizure disorders. There is an ongoing research to understand the safe use of CBD oil. Another study was carried out in 2016, featuring 214 participants. 2 to 5mg of CBD was given to each participant daily to add to their current anti-epilepsy drugs. The participants were carefully monitored for 12 weeks. Throughout the period, the negative side effects were recorded, while the frequency of seizures was carefully observed. It was discovered that the participants had their seizure rate reduce by 36.5 percent.
CBD oil effects on the brain receptors may assist in the management of pain. Research has shown that cannabis can bestow some benefits on the user if administered after chemotherapy. NIH-sponsored preclinical studies are also evaluating the role of cannabis in combating symptoms caused by health conditions such as:
- Chronic pain
- Muscle pain
- Injuries to the spinal cord
Take Sativex for instance, it is multiple sclerosis medications made from CBD and THC. It is approved for the treatment of pain in Canada and the UK. Nevertheless, researchers are of the opinion that CBD oil may exert more benefits due to its anti-inflammatory properties. It is essential that clinical trials be carried out to determine whether or not it should be used as an analgesic.
The impact of CBD on immune system receptors may help minimize the rate of inflammation in the body. CBD oil, in turn, may bestow many benefits for the management of acne. A clinical study published in the Journal of Clinical Investigation discovered that CBD oil inhibits the activity of sebaceous glands. These glands produce an oily substance known as sebum. Sebum is responsible for skin hydration. However, when it is secreted in excess, it leads to acne.
However, users are advised to consult with their dermatologist before using CBD oil for acne. There is a need for more clinical studies to evaluate CBD benefits for acne.
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Research is ongoing on the anti-cancer effects of CBD. According to the National Cancer Institute (NCI), CBD may help in the alleviation of cancer symptoms and side effects of chemotherapy. However, the use of CBD for the treatment of cancer has not yet received a full endorsement from the NCI. Yet, it has promising effects via its ability to regulate inflammatory processes in the body and alter the rate of cell reproduction. CBD also regulates the reproductive ability of some tumor cells.
Diabetes, Queasiness, Epilepsy
One of the reasons why CBD oil garnered so much attention and praise is because it was effectively used to treat an epileptic child.
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Out of four studies carried out on humans, three showed positive outcomes of CBD oil in the treatment of epilepsy. However, due to the absence of rigor and some experimental flaws, researchers have suggested that the current information may not be sufficient to draw strong conclusions regarding the efficacy of using CBD oil in the treatment of seizures.
It is no news that marijuana, the parent plant has a very potent psycho-spiritual effect. However, CBD, which is a less-commonly utilized compound may have similar effects. Users have experienced a marked sedative effect and feelings of relaxation and happiness after ingesting high-quality CBD oil and extracts.
Subsequently, CBD oil is used frequently by meditators for meditation as it helps stem some mental chatter that shows up at intervals during the meditation practice. There are also reports that CBD oil produces positive and remarkable shifts in mindset, allowing the user to see life from a different perspective. Which in most cases, lends itself to new ideas, insights, and closure on the things that bothered them in the past.
Is Cbd Oil Legal?
The simple answer to this question is….it is legal in some countries and illegal in others.
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Certain states that have legalized the use of CBD oil for therapeutic purposes may require users to apply for a medical marijuana license. You should also note that the FDA is yet to approve the use of CBD for therapeutic purposes.
How Is Cbd Oil Made?
It is important that consumers of CBD oil at least have an idea of how it is made.
Production of high-quality CBD oil begins with the selection of viable cannabis genetics. Whether you are getting the oil from raw hemp or cannabis plants, it is essential to use species that is genetically viable.
Popular producers of CBD have worked for years to produce genetically viable species of the plant. While CBD can be extracted from many species, though selecting a species that has a high percentage of CBD is best because it guarantees top quality.
Once the cultivation has been completed, the plant material is then set for the picking. There are many CBD oil products in the market. Some of them are whole plant extracts while others are concentrates of isolated phytochemicals. Virtually every part of the plant is used.
The CBD spectrum is vital because it stimulates the endocannabinoid system. Some CBD isolates are pure due to the quality of genes used in its development.
There are many methods utilized for the production of whole plant CBD oils. The first Cannabinoids oil was produced by Rick Simpson. Using the alcohol extraction method, the plant material is soaked in grain alcohol or any other potent solvent. Soaking extracts the cannabinoids from the plant product into the solvent. The solvent is then evaporated in other to produce the oil.
The Rick Simpson method has been used for commercial production of CBD oil. In recent times, ethanol was used for the extraction of CBD oils. Here, the plant is soaked in ethanol while the resulting alcohol is warmed using the Roto-vap. With the Roto-vap, ethanol solvent does not vaporize into the air. Rather, it is reclaimed for later use. The CBD oil is collected in a separate chamber, free from ethanol solvent, and used for the purpose for which it was meant.
Carbon IV oxide extraction
Co2 extraction is another means used for collection of CBD oil from the hemp plant. The procedure is a bit more technical compared to alcohol extraction and requires more skills and of course devices. Extraction of CO2 requires the use of many chambers that regulate temperature and pressure levels. The pressure and temperature levels in the chambers forces the extraction of CO2 from the cannabinoids, which are then collected in different chambers. With this method, an extractor can be used to separate the cannabinoids and eventually send the preferred oil to a collection point.
These are not the only techniques used for the extraction of cannabinoids, but they are the most popular. \it is important to note that extracting the cannabinoid is just an aspect of CBD oil production.
Flavoring and dilution
The raw oil extracted doesn’t have the best of tastes. Manufacturers have now taken it upon themselves to add flavours to CBD oils in other to give it a better taste – for consumer purpose. Also, consumers may want their oils in varying concentrates, hence producers now dilute their raw oils to accommodate this need. As a consumer, one important thing to take into consideration is where the raw plant is sourced.
The best CBD oil producing companies are incorporated vertically and provide quality control from seed to sale.
Appetite boost in cancer patients
The rise in cancer cases is proportional to the rise in side effects of chemotherapy. For those making use of chemotherapy, one of the adverse effects they are likely to experience is a loss of appetite. This arises from damage to the DNA and the cells, causing nausea, vomiting, loss of energy and reduced appetite. CBD wets the appetite and allows cancer patients to have the desire for food. Promoting nourishment and ultimately boosting the immune system. The ideal dosage is 2.5mg of THC administered orally with 1mg of CBD daily for six weeks.
At Least 100 million Americans suffer from chronic discomfort for various reasons. Discomfort may occur in the joints, the organs, body cavities, ligaments, and bones. Sometimes, these discomforts may be triggered by diseases like ulcerative colitis, fibromyalgia and Lyme disease. Constant illness can cripple the body system while the pain can leave the patient immobilized. Studies have shown that CBD can promote healthiness of the joints and muscles, and also stabilize organ function. Its action on the endocannabinoid system causes the nociceptive pathways to reduce swelling and ultimately prevent pain. The ideal CBD oil dosage for this is 2.5-3.0 mg for 25 days. This is administered sublingually and has cumulative benefits.
Movement disorders associated with Huntington’s disease
Huntington’s disease is a disorder of the central nervous system that causes degeneration of neurons in the brain. Symptoms include poor functional capabilities, poor coordination, jerky and uncoordinated movements. Degeneration of the nerves and the neural system is inhibited by the action of CBD on the CB1 and CB2 receptors. This is achieved by containing the toxicity in microglial cells and also through the suppression of inflammation to promote relief to the muscles and joints. This serves as a neuroprotector in degenerative nerve diseases. The recommended CBD dosage is 10 mg of CBD daily for six weeks.
Management of sleep disorders
There is a difference between sleep disorders and sleeping disorders. Sleep disorders include narcolepsy, obstructive sleep apnea, and postponed sleep phase syndrome. Research has shown that CBD helps combat sleep disorders. The optimal dosage to enjoy this benefit is a daily dose of 40-160 mg administered sublingually.
Reduces symptom of multiple sclerosis
Multiple sclerosis is a neurodegenerative and autoimmune disorder that affects major parts of the nervous system including the spinal cord, the brain, and the optic nerves. It is accompanied by several complications such as persistent pain, fatigue, vision loss, and poor coordination. Compounds like CBD protects the nervous system from the autoimmune attacks by suppressing the immune system. When the body’s immune system is suppressed, it will not be able to attack the nervous system. The optimum dosage is 2.5-120 mg of a combined THC-CBD therapy administered daily for eight weeks. Eight sprays may be used within three hours, while a maximum of 48 sprays may be used within a day (24 hours).
Regular intake of the recommended dose (4 drops 3 times daily) creates a balance in the nervous system, provides the best antioxidant support, assists in healthy inflammation reaction, and promotes psychological balance.
For those with specific health disorders, an increased dose of CBD oil is required to provide relief. According to the National Cancer Institute, CBD oil overdose is near impossible. This is because cannabinoid receptors are not located in the brainstem regions regulating respiration like the opioid receptors, hence fatal overdoses of cannabinoids does not occur.
Optimizing CBD oil Dosage
Consumers must inspect items thoroughly to verify that they are consuming the right amounts. Also, consult your physician on any health disturbance that might be a concern to you.
Does CBD or other hemp-based constituents show up during a drug test?
Many drug-tests target tetrahydrocannabinol and not CBD. The CBD compound is a legal hemp-based ingredient in many countries. However, research has shown that consumption of hemp-based foods can cause positive results during blood or urine tests. Users are advised not to take CBD oil or any CBD or THC-based products if they are billed for any form of drug test.
Users are advised to consult with their employer, drug screening company or healthcare provider prior to a drug test.
Despite the fact that, there are many benefits to derive from CBD oil. However, a majority of CBD products presently in the market hasn’t been through the quality assurance standards test. Thus, ensure to check every CBD products for the quality seal prior to purchasing.
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